Carcinostatic Methanesulfonic Acid Esters of Some Aminoglycols

Carcinostatic Methanesulfonic Acid Esters of Some Aminoglycols

Seven methanesulfonic esters analogues of aminoglycols were prepared and their autitumor activity was investigated with two kinds of rat tumors. Of these compounds, 3, 3'-dimesyloxy-N-methyldipropylamine (No. 838), was proved to be the most effective and seems to be a promising candidate for cl...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1964/08/25, Vol.12(8), pp.954-958
Hauptverfasser: Sakurai, Yoshio, El-Merzabani, Mahmoud M.
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents
Chemistry, Pharmaceutical
Esters
Mesylates
Neoplasms
Old Medline
Pharmacology
Rats
Sarcoma
Sarcoma, Yoshida
Sulfonic Acids
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Zusammenfassung:Seven methanesulfonic esters analogues of aminoglycols were prepared and their autitumor activity was investigated with two kinds of rat tumors. Of these compounds, 3, 3'-dimesyloxy-N-methyldipropylamine (No. 838), was proved to be the most effective and seems to be a promising candidate for clinical trial.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.12.954