Lack of Antibody Activity Directed against the Most Common Human Bacteria in Human Myeloma Protein

Lack of Antibody Activity Directed against the Most Common Human Bacteria in Human Myeloma Protein

The fact that sera of germ-free animals contain very little Ig suggests that most Ig probably correspond to antibacterial antibodies. We have detected an antibacterial activity against 40 bacterial strains, pathogenic and nonpathogenic, in 85 M-component of human origin. This work has been conducted...

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Veröffentlicht in:The Journal of immunology (1950) 1976-11, Vol.117 (5 Part 2), p.2042-2044
Hauptverfasser: Pillot, Jacques, Creau-Goldberg, Nicole, Gonzales, Yolanda
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies, Bacterial - analysis
Fluorescent Antibody Technique
Humans
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Multiple Myeloma - immunology
Myeloma Proteins - immunology
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container_end_page 2044
container_issue 5 Part 2
container_start_page 2042
container_title The Journal of immunology (1950)
container_volume 117
creator Pillot, Jacques
Creau-Goldberg, Nicole
Gonzales, Yolanda
description The fact that sera of germ-free animals contain very little Ig suggests that most Ig probably correspond to antibacterial antibodies. We have detected an antibacterial activity against 40 bacterial strains, pathogenic and nonpathogenic, in 85 M-component of human origin. This work has been conducted by indirect immunofluorescence withipure labeled antibodies. The reasons for which indirect immunofluorescence seems to be the best technique for this kind of research are discussed. No activity whatsoever could be detected. The reasons of this lack of activity remain to be explained.
doi_str_mv 10.4049/jimmunol.117.5_Part_2.2042
format Article
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subjects Antibodies, Bacterial - analysis
Fluorescent Antibody Technique
Humans
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Multiple Myeloma - immunology
Myeloma Proteins - immunology
title Lack of Antibody Activity Directed against the Most Common Human Bacteria in Human Myeloma Protein
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