Lack of Antibody Activity Directed against the Most Common Human Bacteria in Human Myeloma Protein

The fact that sera of germ-free animals contain very little Ig suggests that most Ig probably correspond to antibacterial antibodies. We have detected an antibacterial activity against 40 bacterial strains, pathogenic and nonpathogenic, in 85 M-component of human origin. This work has been conducted by indirect immunofluorescence withipure labeled antibodies. The reasons for which indirect immunofluorescence seems to be the best technique for this kind of research are discussed. No activity whatsoever could be detected. The reasons of this lack of activity remain to be explained.