HIGH PERFORMANCE LIQUID CHROMATOGRAPHY OF NATURAL PRODUCTS: I. SEPARATION OF CEPHALOSPORIN C DERIVATIVES AND CEPHALOSPORIN ANTIBIOTICS; ISOLATION OF CEPHALOSPORIN C FROM FERMENTATION BROTH

Microbonded propylamine silica with a solvent system containing acetic acid, methanol, acetonitrile and water (2:4:7.5:86.5) is suitable for an efficient separation of mixtures containing several closely related cephem derivatives. The same system with preparative columns was used for the isolation...

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Veröffentlicht in:	Journal of antibiotics 1976, Vol.29(9), pp.902-906
Hauptverfasser:	MILLER, ROGER D., NEUSS, NORBERT
Format:	Artikel
Sprache:	eng
Schlagworte:	Acremonium - metabolism Cephalosporins - biosynthesis Cephalosporins - isolation & purification Fermentation Methods Solvents
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description	Microbonded propylamine silica with a solvent system containing acetic acid, methanol, acetonitrile and water (2:4:7.5:86.5) is suitable for an efficient separation of mixtures containing several closely related cephem derivatives. The same system with preparative columns was used for the isolation of cephalosporin C directly from the filtered broth of C. acremonium fermentation.
doi_str_mv	10.7164/antibiotics.29.902
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subjects	Acremonium - metabolism Cephalosporins - biosynthesis Cephalosporins - isolation & purification Fermentation Methods Solvents
title	HIGH PERFORMANCE LIQUID CHROMATOGRAPHY OF NATURAL PRODUCTS: I. SEPARATION OF CEPHALOSPORIN C DERIVATIVES AND CEPHALOSPORIN ANTIBIOTICS; ISOLATION OF CEPHALOSPORIN C FROM FERMENTATION BROTH
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