HIGH PERFORMANCE LIQUID CHROMATOGRAPHY OF NATURAL PRODUCTS: I. SEPARATION OF CEPHALOSPORIN C DERIVATIVES AND CEPHALOSPORIN ANTIBIOTICS; ISOLATION OF CEPHALOSPORIN C FROM FERMENTATION BROTH

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY OF NATURAL PRODUCTS: I. SEPARATION OF CEPHALOSPORIN C DERIVATIVES AND CEPHALOSPORIN ANTIBIOTICS; ISOLATION OF CEPHALOSPORIN C FROM FERMENTATION BROTH

Microbonded propylamine silica with a solvent system containing acetic acid, methanol, acetonitrile and water (2:4:7.5:86.5) is suitable for an efficient separation of mixtures containing several closely related cephem derivatives. The same system with preparative columns was used for the isolation...

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Veröffentlicht in:Journal of antibiotics 1976, Vol.29(9), pp.902-906
Hauptverfasser: MILLER, ROGER D., NEUSS, NORBERT
Format: Artikel
Sprache:eng
Schlagworte:
Acremonium - metabolism
Cephalosporins - biosynthesis
Cephalosporins - isolation & purification
Fermentation
Methods
Solvents
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Zusammenfassung:Microbonded propylamine silica with a solvent system containing acetic acid, methanol, acetonitrile and water (2:4:7.5:86.5) is suitable for an efficient separation of mixtures containing several closely related cephem derivatives. The same system with preparative columns was used for the isolation of cephalosporin C directly from the filtered broth of C. acremonium fermentation.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.29.902