MICROBIAL TRANSFORMATION OF DAUNOMYCINONE BY STREPTOMYCES AUREOFACIENS B-96
Daunomycinone, aglycone of the anthracycline antibiotic daunomycin, was transformed by a washed mycelia of Streptomyces aureofaciens B-96 in a buffer solution containing sucrose; the obtained product, dihydrodaunomycinone(9-(1-hydroxyethyl)-7, 8, 9, 10-tetrahydro-6, 7, 9, 11- tetrahydroxy-4-methoxy-...
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| Veröffentlicht in: | Journal of antibiotics 1976, Vol.29(11), pp.1199-1202 |
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| container_end_page | 1202 |
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| container_issue | 11 |
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| container_title | Journal of antibiotics |
| container_volume | 29 |
| creator | KARNETOVÁ, JAROSLAVA MATEJU, JIRÍ SEDMERA, PETR VOKOUN, JINDRICH VANEK, ZDENKO |
| description | Daunomycinone, aglycone of the anthracycline antibiotic daunomycin, was transformed by a washed mycelia of Streptomyces aureofaciens B-96 in a buffer solution containing sucrose; the obtained product, dihydrodaunomycinone(9-(1-hydroxyethyl)-7, 8, 9, 10-tetrahydro-6, 7, 9, 11- tetrahydroxy-4-methoxy-5, 12-naphthacenequinone), was identified by measuring basic physicochemical characteristics (IR, UV and visible spectra, mass spectra and NMR, optical rotation and m. p.). |
| doi_str_mv | 10.7164/antibiotics.29.1199 |
| format | Article |
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Antibiot.</addtitle><description>Daunomycinone, aglycone of the anthracycline antibiotic daunomycin, was transformed by a washed mycelia of Streptomyces aureofaciens B-96 in a buffer solution containing sucrose; the obtained product, dihydrodaunomycinone(9-(1-hydroxyethyl)-7, 8, 9, 10-tetrahydro-6, 7, 9, 11- tetrahydroxy-4-methoxy-5, 12-naphthacenequinone), was identified by measuring basic physicochemical characteristics (IR, UV and visible spectra, mass spectra and NMR, optical rotation and m. p.).</description><subject>Biotransformation</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Daunorubicin - analysis</subject><subject>Daunorubicin - metabolism</subject><subject>Hydrolysis</subject><subject>Streptomyces aureofaciens - metabolism</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkD1vwjAYhK2qX5T2F7RDpm6h_giOPYY0aaNCXIUwMFmO47SpgNA4DP33BQUhlnul9-6e4QB4RHDkI-q9qE1XF3XT1dqOMB8hxPkFGCDGkIs8yi_BAEKMXMYwvAV31v5ASHzisxtwzfDY43QAPmZJmIlJEkydPAvSeSyyWZAnInVE7LwGi1TMlmGSijRyJktnnmfRZ354RXMnWGSRiIMwidK5M3E5vQdXlVpZ83C8Q7CIozx8d6fiLQmDqasp9DvXpwWpdIUxrpT2uClhyZhXFJBXZMy4h8rSQN_3NVV4jDXUFUPcY1TDMebIYDIEzz132za_O2M7ua6tNquV2phmZyUjlDBvL0NA-qBuG2tbU8ltW69V-ycRlIcF5dmCEnN5WHDfejrid8XalKdOP9neTnv7x3bqy5xs1e4pK3OORJyyHnvUA_8U1N-qlWZD_gFp24SW</recordid><startdate>19760101</startdate><enddate>19760101</enddate><creator>KARNETOVÁ, JAROSLAVA</creator><creator>MATEJU, JIRÍ</creator><creator>SEDMERA, PETR</creator><creator>VOKOUN, JINDRICH</creator><creator>VANEK, ZDENKO</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19760101</creationdate><title>MICROBIAL TRANSFORMATION OF DAUNOMYCINONE BY STREPTOMYCES AUREOFACIENS B-96</title><author>KARNETOVÁ, JAROSLAVA ; MATEJU, JIRÍ ; SEDMERA, PETR ; VOKOUN, JINDRICH ; VANEK, ZDENKO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c607t-76b3fcf222fac49ed0d884bb09f358941dde0777c6a252c0cf819486c05291e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Biotransformation</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Daunorubicin - analysis</topic><topic>Daunorubicin - metabolism</topic><topic>Hydrolysis</topic><topic>Streptomyces aureofaciens - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KARNETOVÁ, JAROSLAVA</creatorcontrib><creatorcontrib>MATEJU, JIRÍ</creatorcontrib><creatorcontrib>SEDMERA, PETR</creatorcontrib><creatorcontrib>VOKOUN, JINDRICH</creatorcontrib><creatorcontrib>VANEK, ZDENKO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KARNETOVÁ, JAROSLAVA</au><au>MATEJU, JIRÍ</au><au>SEDMERA, PETR</au><au>VOKOUN, JINDRICH</au><au>VANEK, ZDENKO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MICROBIAL TRANSFORMATION OF DAUNOMYCINONE BY STREPTOMYCES AUREOFACIENS B-96</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1976-01-01</date><risdate>1976</risdate><volume>29</volume><issue>11</issue><spage>1199</spage><epage>1202</epage><pages>1199-1202</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>Daunomycinone, aglycone of the anthracycline antibiotic daunomycin, was transformed by a washed mycelia of Streptomyces aureofaciens B-96 in a buffer solution containing sucrose; the obtained product, dihydrodaunomycinone(9-(1-hydroxyethyl)-7, 8, 9, 10-tetrahydro-6, 7, 9, 11- tetrahydroxy-4-methoxy-5, 12-naphthacenequinone), was identified by measuring basic physicochemical characteristics (IR, UV and visible spectra, mass spectra and NMR, optical rotation and m. p.).</abstract><cop>Japan</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>825496</pmid><doi>10.7164/antibiotics.29.1199</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of Antibiotics, 1976, Vol.29(11), pp.1199-1202 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| source | J-STAGE Free; MEDLINE |
| subjects | Biotransformation Chemical Phenomena Chemistry Daunorubicin - analysis Daunorubicin - metabolism Hydrolysis Streptomyces aureofaciens - metabolism |
| title | MICROBIAL TRANSFORMATION OF DAUNOMYCINONE BY STREPTOMYCES AUREOFACIENS B-96 |
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