MICROBIAL TRANSFORMATION OF DAUNOMYCINONE BY STREPTOMYCES AUREOFACIENS B-96

MICROBIAL TRANSFORMATION OF DAUNOMYCINONE BY STREPTOMYCES AUREOFACIENS B-96

Daunomycinone, aglycone of the anthracycline antibiotic daunomycin, was transformed by a washed mycelia of Streptomyces aureofaciens B-96 in a buffer solution containing sucrose; the obtained product, dihydrodaunomycinone(9-(1-hydroxyethyl)-7, 8, 9, 10-tetrahydro-6, 7, 9, 11- tetrahydroxy-4-methoxy-...

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Veröffentlicht in:Journal of antibiotics 1976, Vol.29(11), pp.1199-1202
Hauptverfasser: KARNETOVÁ, JAROSLAVA, MATEJU, JIRÍ, SEDMERA, PETR, VOKOUN, JINDRICH, VANEK, ZDENKO
Format: Artikel
Sprache:eng
Schlagworte:
Biotransformation
Chemical Phenomena
Chemistry
Daunorubicin - analysis
Daunorubicin - metabolism
Hydrolysis
Streptomyces aureofaciens - metabolism
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Beschreibung
Zusammenfassung:Daunomycinone, aglycone of the anthracycline antibiotic daunomycin, was transformed by a washed mycelia of Streptomyces aureofaciens B-96 in a buffer solution containing sucrose; the obtained product, dihydrodaunomycinone(9-(1-hydroxyethyl)-7, 8, 9, 10-tetrahydro-6, 7, 9, 11- tetrahydroxy-4-methoxy-5, 12-naphthacenequinone), was identified by measuring basic physicochemical characteristics (IR, UV and visible spectra, mass spectra and NMR, optical rotation and m. p.).
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.29.1199