The Suppressive Effect of Interferon on the Ability of Mouse Spleen Cells Synthesizing IgE to Sensitize Rat Skin for Heterologous Adoptive Cutaneous Anaphylaxis
Mouse spleen cells which are synthesizing IgE can sensitize rat skin for HACA. When such cells are treated with mouse interferon, their ability to sensitize rat skin is reduced or completely inhibited. Two hundred PRD50 units of interferon reduced HACA reactions by more than 50%; 600 units gave comp...
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| Veröffentlicht in: | The Journal of immunology (1950) 1976-10, Vol.117 (4), p.1063-1066 |
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| container_end_page | 1066 |
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| container_issue | 4 |
| container_start_page | 1063 |
| container_title | The Journal of immunology (1950) |
| container_volume | 117 |
| creator | Ngan, Johnson Lee, Spencer H. S Kind, Leon S |
| description | Mouse spleen cells which are synthesizing IgE can sensitize rat skin for HACA. When such cells are treated with mouse interferon, their ability to sensitize rat skin is reduced or completely inhibited. Two hundred PRD50 units of interferon reduced HACA reactions by more than 50%; 600 units gave complete inhibition. Interferon may act by inhibiting IgE synthesis and/or release. |
| doi_str_mv | 10.4049/jimmunol.117.4.1063 |
| format | Article |
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Interferon may act by inhibiting IgE synthesis and/or release.</description><subject>Animals</subject><subject>Dose-Response Relationship, Immunologic</subject><subject>Immunoglobulin E - biosynthesis</subject><subject>Immunosuppressive Agents</subject><subject>Interferons - pharmacology</subject><subject>Mice</subject><subject>Ovalbumin - pharmacology</subject><subject>Passive Cutaneous Anaphylaxis</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Species Specificity</subject><subject>Spleen - immunology</subject><subject>Time Factors</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkc2O0zAUhS3EXxl4Alh4BasUO3GcZllVhak0CIkOa8txrlsPjh1sh9J5Gh4VlwwIydKVfM75rq2D0GtKloyw9v2dGYbJebuktFmyJSW8eoQWtK5JwTnhj9GCkLIsaMOb5-hFjHeEEE5K9gw9bZumZXSBft0eAe-ncQwQo_kBeKs1qIS9xjuXIGgI3uF8UvatO2NNOl_ET36KOThaAIc3YG3E-7PLpmjujTvg3WGLk8d7cNEkcw_4i0x4_804rH3A15DR3vpDpuB178d0Wb2ZknTw58rJ8Xi28qeJL9ETLW2EVw_zCn39sL3dXBc3nz_uNuubQjFWpgJUV9K2Vg3pyxXXeQJIXQKltVY907QvAVZN16yokrRra963nWR8VSkCTHXVFXo7c8fgv08QkxhMVPlj85PEquIVpVWTjdVsVMHHGECLMZhBhrOgRFxqEX9rEbkWwcSllpx684CfugH6f5m5hyy_m-WjORxPJoCIg7Q2m6k4nU7_gX4DTTqczQ</recordid><startdate>197610</startdate><enddate>197610</enddate><creator>Ngan, Johnson</creator><creator>Lee, Spencer H. 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| identifier | ISSN: 0022-1767 |
| ispartof | The Journal of immunology (1950), 1976-10, Vol.117 (4), p.1063-1066 |
| issn | 0022-1767 1550-6606 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83631137 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Dose-Response Relationship, Immunologic Immunoglobulin E - biosynthesis Immunosuppressive Agents Interferons - pharmacology Mice Ovalbumin - pharmacology Passive Cutaneous Anaphylaxis Rabbits Rats Species Specificity Spleen - immunology Time Factors |
| title | The Suppressive Effect of Interferon on the Ability of Mouse Spleen Cells Synthesizing IgE to Sensitize Rat Skin for Heterologous Adoptive Cutaneous Anaphylaxis |
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