The Suppressive Effect of Interferon on the Ability of Mouse Spleen Cells Synthesizing IgE to Sensitize Rat Skin for Heterologous Adoptive Cutaneous Anaphylaxis

The Suppressive Effect of Interferon on the Ability of Mouse Spleen Cells Synthesizing IgE to Sensitize Rat Skin for Heterologous Adoptive Cutaneous Anaphylaxis

Mouse spleen cells which are synthesizing IgE can sensitize rat skin for HACA. When such cells are treated with mouse interferon, their ability to sensitize rat skin is reduced or completely inhibited. Two hundred PRD50 units of interferon reduced HACA reactions by more than 50%; 600 units gave comp...

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Veröffentlicht in:The Journal of immunology (1950) 1976-10, Vol.117 (4), p.1063-1066
Hauptverfasser: Ngan, Johnson, Lee, Spencer H. S, Kind, Leon S
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Dose-Response Relationship, Immunologic
Immunoglobulin E - biosynthesis
Immunosuppressive Agents
Interferons - pharmacology
Mice
Ovalbumin - pharmacology
Passive Cutaneous Anaphylaxis
Rabbits
Rats
Species Specificity
Spleen - immunology
Time Factors
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Zusammenfassung:Mouse spleen cells which are synthesizing IgE can sensitize rat skin for HACA. When such cells are treated with mouse interferon, their ability to sensitize rat skin is reduced or completely inhibited. Two hundred PRD50 units of interferon reduced HACA reactions by more than 50%; 600 units gave complete inhibition. Interferon may act by inhibiting IgE synthesis and/or release.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.117.4.1063