Potentiation of cutaneous reactivity and blood leucocyte histamine release by deuterium oxide in human beings

Deuterium oxide (D2O) is known to potentiate non-cytotoxic histamine release in vitro. It has been shown (5) that D2O could also potentiate in vivo immediate-type hypersensitivity in dogs and monkeys. Present studies demonstrate potentiation in vivo by D2O of the cutaneous reactivity in 48/80, PHA a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta allergologica 1976-10, Vol.31 (5), p.367-372
Hauptverfasser:	Vervloet, D, Vellieux, P, Charpin, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Deuterium - pharmacology Histamine Release - drug effects Humans Hypersensitivity, Immediate - immunology Lectins - pharmacology Leukocytes - metabolism Mites - immunology p-Methoxy-N-methylphenethylamine - pharmacology Skin Tests
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Deuterium oxide (D2O) is known to potentiate non-cytotoxic histamine release in vitro. It has been shown (5) that D2O could also potentiate in vivo immediate-type hypersensitivity in dogs and monkeys. Present studies demonstrate potentiation in vivo by D2O of the cutaneous reactivity in 48/80, PHA and Dermatophagoides cutaneous reactions in human beings. PHA histamine release from human leucocytes is also potentiated by D2O in vitro.
ISSN:	0001-5148