Canine leishmaniasis with amyloidosis

Visceral leishmaniasis was diagnosed in a 2-year-old male Great Dane imported from Greece. The clinical signs included anemia, diarrhea, weight loss, proteinuria, and hyperglobulinemia with increases in α2- and γ-regions. At necropsy there was plasmalymphocytic and macrophage infiltration of spleen,...

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Veröffentlicht in:	Veterinary pathology 1976-01, Vol.13 (5), p.365-373
Hauptverfasser:	George, J.W, Nielsen, S.W, Shiverly, J.N, Hopek, S, Mroz, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloidosis - complications Amyloidosis - veterinary Animals Dog Diseases - parasitology Dogs Leishmania donovani Leishmaniasis, Visceral - complications Leishmaniasis, Visceral - parasitology Leishmaniasis, Visceral - veterinary Macrophages - parasitology Male Phlebotomus Spleen - pathology
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Zusammenfassung:	Visceral leishmaniasis was diagnosed in a 2-year-old male Great Dane imported from Greece. The clinical signs included anemia, diarrhea, weight loss, proteinuria, and hyperglobulinemia with increases in α2- and γ-regions. At necropsy there was plasmalymphocytic and macrophage infiltration of spleen, macrophage infiltration of bone marrow, intracellular organisms of macrophages having the ultrastructural characteristics of Leishmania species, and severe amyloidosis of the spleen, liver, and kidney.
ISSN:	0300-9858 1544-2217
DOI:	10.1177/030098587601300506