Erythrocyte Glutathione-levels in Patients of a Mental Hospital

THE work of Beutler 1 on erythrocyte glutathione ‘instability’ has demonstrated the significance of the glutathione content of red cells for the maintenance of overall erythrocyte structure (and presumably function). In addition, Rigas et al. 2 have shown how the interaction of hæmoglobin and oxidiz...

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Veröffentlicht in:Nature (London) 1964-05, Vol.202 (4935), p.904-904
Hauptverfasser: ELLMAN, GEORGE L., GAN, GEORGE L.
Format: Artikel
Sprache:eng
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Zusammenfassung:THE work of Beutler 1 on erythrocyte glutathione ‘instability’ has demonstrated the significance of the glutathione content of red cells for the maintenance of overall erythrocyte structure (and presumably function). In addition, Rigas et al. 2 have shown how the interaction of hæmoglobin and oxidized glutathione can lead to increased rates of splenic erythrocyte destruction. A number of disease states have been related to increased instability of erythrocyte glutathione; for example, Theil et al. 3 have shown a significant decrease of blood glutathione-levels in patients with acute renal insufficiency.
ISSN:0028-0836
1476-4687
DOI:10.1038/202904a0