Preparation of 1-acyl-2-succinyl glycero-3-phosphorylcholine and evidence against its involvement in succinate dehydrogenase action

Preparation of 1-acyl-2-succinyl glycero-3-phosphorylcholine and evidence against its involvement in succinate dehydrogenase action

1-Acyl-2-succinyl glycero-3-phosphorylcholine (GPC) was synthesized and its properties described. Although 1-acyl-2-succinyl GPC is a good substrate for succinate dehydrogenase, experiments on the incorporation of [2,3- 14C]succinate into mitochondrial lipids gave no evidence to indicate that it is...

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Veröffentlicht in:Chemistry and physics of lipids 1976-11, Vol.17 (4), p.407-415
Hauptverfasser: Brain, F.H., Davison, A.N., Natarjan, V., Sastry, P.S.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cyanides - pharmacology
Glycerylphosphorylcholine - analogs & derivatives
Lysophosphatidylcholines
Microsomes, Liver - drug effects
Microsomes, Liver - enzymology
Mitochondria, Liver - drug effects
Mitochondria, Liver - enzymology
Phospholipases
Rats
Snake Venoms
Succinate Dehydrogenase - metabolism
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Zusammenfassung:1-Acyl-2-succinyl glycero-3-phosphorylcholine (GPC) was synthesized and its properties described. Although 1-acyl-2-succinyl GPC is a good substrate for succinate dehydrogenase, experiments on the incorporation of [2,3- 14C]succinate into mitochondrial lipids gave no evidence to indicate that it is an intermediate in the enzymic oxidation of succinate to fumarate, as has been suggested earlier.
ISSN:0009-3084
1873-2941
DOI:10.1016/0009-3084(76)90042-6