Immunodeficiency, xanthomas and obstructive liver disease

Chronic obstructive liver disease and secondary hyperlipidemia developed in an immunodeficient boy. Sequential addition of cholestyramine and phenobarbital to his medical regimen, following an initial response to bile drainage, resulted in the disappearance of xanthomas and pruritus, and the restora...

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Veröffentlicht in:	The American journal of medicine 1976-09, Vol.61 (3), p.393-400
Hauptverfasser:	Isenberg, J.Nevin, Hansom, Russell F., Williams, Gail C., Zavoral, James, Page, Arthur R., Sharp, Harvey L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bile Acids and Salts - metabolism Chenodeoxycholic Acid - metabolism Child Cholestyramine Resin - pharmacology Cholic Acids - metabolism Humans Hypercholesterolemia - complications Hyperlipidemias - complications Immunologic Deficiency Syndromes - complications Liver Diseases - complications Male Phenobarbital - pharmacology Pruritus - complications Xanthomatosis - complications
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Beschreibung
Zusammenfassung:	Chronic obstructive liver disease and secondary hyperlipidemia developed in an immunodeficient boy. Sequential addition of cholestyramine and phenobarbital to his medical regimen, following an initial response to bile drainage, resulted in the disappearance of xanthomas and pruritus, and the restoration of normal serum concentrations of liplds and bile acids. This improvement may result from shifting the bile acid pool from the peripheral blood compartment to the enterohepatlc circulation.
ISSN:	0002-9343 1555-7162
DOI:	10.1016/0002-9343(76)90377-6