Uptake and storage of 14C -labeled endrin by the livers and brains of pesticide-susceptible and resistant mosquitofish

The rate of uptake and storage patterns of endrin in the livers and brains of pesticide-susceptible and resistant mosquitofish is investigated as possible mechanisms of endrin resistance. Susceptible fish uptake endrin into the brain and liver fractions more quickly than resistant fish do. Resistant fish display a more efficient blood-brain barrier. If the chloroform-methanol/hexane ratio is interpreted as an Index of endrin binding to tissues, the brains of resistant fish show a lower degree of endrin binding than those of susceptible fish following exposure to high insecticide concentrations do.