Effect of Iron-deficiency Anæmia on the Metabolism of the Heterogenic Hæmoglobins in Sickle Cell Trait
HÆMOGLOBIN S is found in a concentration of 35–45 per cent of the total hæmoglobin in most individuals with sickle cell trait under non-stress conditions 1,2 . It is believed that the relative concentrations of the heterogenic hæmoglobins, hæmoglobin S and hæmoglobin A, in these individuals remain f...
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Veröffentlicht in: | Nature (London) 1964-05, Vol.202 (4931), p.499-501 |
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Zusammenfassung: | HÆMOGLOBIN S is found in a concentration of 35–45 per cent of the total hæmoglobin in most individuals with sickle cell trait under non-stress conditions
1,2
. It is believed that the relative concentrations of the heterogenic hæmoglobins, hæmoglobin S and hæmoglobin A, in these individuals remain fairly constant throughout life. However, on rare occasions, changes in these relative concentrations have been demonstrated. In 1956, Zuelzer, Neel and Robinson
3
described an 8-month-old infant with sickle cell trait and severe iron-deficiency anæmia in whom hæmoglobin S could not be demonstrated by paper electrophoresis until the anæmia had been corrected with iron therapy. More recently, Heller, Yakulis, Epstein and Friedland
4
have described a patient with sickle cell trait and coexistent megaloblastic anæmia in whom the hæmoglobin S concentration increased from an initial level of 10.6 per cent to a concentration of 38.5 per cent following therapy with folic acid. |
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ISSN: | 0028-0836 1476-4687 |
DOI: | 10.1038/202499a0 |