Streptomycinoid Antibiotics: Synergism by Puromycin

Streptomycinoid Antibiotics: Synergism by Puromycin

Puromycin synergizes the lethal action of streptomycin and related antibiotics. This is interpreted to mean that puromycin action uncovers a sensitive site (or sites) on the 30S ribosome. The streptomycinoid antibiotics can then associate more readily with the ribosome and inhibit further synthesis...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1964-11, Vol.146 (3645), p.772-774
Hauptverfasser: White, James R., White, Helen Lyng
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents
Antibiotics
Chloramphenicol
Escherichia coli
Kanamycin
Messenger RNA
Mode of action
Monkeys
Neomycin
Old Medline
Paromomycin
Pharmacology
Phenotypes
Protein synthesis
Puromycin
Ribosomes
RNA
Streptomycin
Synergism
Transferrins
Viomycin
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Beschreibung
Zusammenfassung:Puromycin synergizes the lethal action of streptomycin and related antibiotics. This is interpreted to mean that puromycin action uncovers a sensitive site (or sites) on the 30S ribosome. The streptomycinoid antibiotics can then associate more readily with the ribosome and inhibit further synthesis of valid protein.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.146.3645.772