Endogenous Metabolic Factor in Schizophrenic Behavior

Endogenous Metabolic Factor in Schizophrenic Behavior

Exacerbations of schizophrenic behavior are associated with elevations of urinary tryptophan metabolites. Free tryptophan and methionine possibly arising from the breakdown of muscle protein may act like an endogenous metabolic factor which enhances behavioral worsening. Some of the apparently spont...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1964-04, Vol.144 (3616), p.311-313
Hauptverfasser: Berlet, H. H., Bull, C., Himwich, H. E., Kohl, H., Matsumoto, K., Pscheidt, G. R., Spaide, J., Tourlentes, T. T., Valverde, J. M.
Format: Artikel
Sprache:eng
Schlagworte:
Amino acid metabolism
Amino acids
Creatine
Creatinine
Diet
Dietary Proteins
Excretion
Humans
Hydroxyindoleacetic Acid
Indoleacetic Acids
Indoles
Lesions
Methionine
Muscle Proteins
Myelin
Nervous system diseases
Nitrogen
Old Medline
Proteins - metabolism
Schizophrenia
Schizophrenic Psychology
Tryptamines
Tryptophan
Urine
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Zusammenfassung:Exacerbations of schizophrenic behavior are associated with elevations of urinary tryptophan metabolites. Free tryptophan and methionine possibly arising from the breakdown of muscle protein may act like an endogenous metabolic factor which enhances behavioral worsening. Some of the apparently spontaneous activations of psychotic symptoms may be intensified by the endogenous liberation of these two compounds.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.144.3616.311