Effects of bromocriptine on central dopaminergic receptors

Bromocriptine injected to rats induces an increase of cAMP levels in the striatum in vivo. The time course of this increase is very similar to that of apomorphine. However bromocriptine does not stimulate striatal dopamine-sensitive adenylate cyclase but surprisingly antagonized the activation of th...

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Veröffentlicht in:	Life sciences (1973) 1976-07, Vol.19 (2), p.225-232
Hauptverfasser:	Trabucchi, M., Spano, P.F., Tonon, G.C., Frattola, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Animals Bromocriptine - pharmacology Corpus Striatum - drug effects Corpus Striatum - enzymology Corpus Striatum - metabolism Cyclic AMP - metabolism Dopamine Antagonists Enzyme Activation Ergolines - pharmacology Male Rats Receptors, Drug - drug effects
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