Effects of bromocriptine on central dopaminergic receptors

Effects of bromocriptine on central dopaminergic receptors

Bromocriptine injected to rats induces an increase of cAMP levels in the striatum in vivo. The time course of this increase is very similar to that of apomorphine. However bromocriptine does not stimulate striatal dopamine-sensitive adenylate cyclase but surprisingly antagonized the activation of th...

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Veröffentlicht in:Life sciences (1973) 1976-07, Vol.19 (2), p.225-232
Hauptverfasser: Trabucchi, M., Spano, P.F., Tonon, G.C., Frattola, L.
Format: Artikel
Sprache:eng
Schlagworte:
Adenylyl Cyclases - metabolism
Animals
Bromocriptine - pharmacology
Corpus Striatum - drug effects
Corpus Striatum - enzymology
Corpus Striatum - metabolism
Cyclic AMP - metabolism
Dopamine Antagonists
Enzyme Activation
Ergolines - pharmacology
Male
Rats
Receptors, Drug - drug effects
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Zusammenfassung:Bromocriptine injected to rats induces an increase of cAMP levels in the striatum in vivo. The time course of this increase is very similar to that of apomorphine. However bromocriptine does not stimulate striatal dopamine-sensitive adenylate cyclase but surprisingly antagonized the activation of this enzyme elicited by dopamine. Possible hypotheses on various sites of action of the drug are discussed.
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(76)90394-5