Comparison of the efficacy of fibrates on hypertriglyceridemic phenotypes with different genetic and clinical characteristics

Hypertriglyceridemia is a frequent and heterogeneous clinical trait, which modulates the risk of disease. Fibrates constitute an effective class of triglyceride-lowering agents. OBJECTIVETo evaluate the effect of fibrates on fasting plasma triglycerides and other lipids levels in hypertriglyceridemia phenotypes with different genetic and clinical characteristics. METHODSThis study included 146 fasting adults15 with lactescent plasma and severe hypertriglyceridemia (triglyceride≥10 mmol/l) and 131 with clear plasma and moderate hypertriglyceridemia (2≤triglycerides