The adsorption of sympathomimetic agents by activated carbon hemoperfusion

The adsorption of sympathomimetic agents by activated carbon hemoperfusion

Sympathomimetic agents with mixed and pure alpha and beta adrenergic activity are adsorbed by coconut shell activated carbon from blood, sufficiently rapidly to markedly reduce the activity of these agents. The results of this study suggest that the site of injection of sympathomimetic agents being...

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Veröffentlicht in:Transactions - American Society for Artificial Internal Organs 1976, Vol.22, p.425-430
Hauptverfasser: Horres, C R, Hill, J B, Ellis, F W
Format: Artikel
Sprache:eng
Schlagworte:
Adsorption
Animals
Blood Pressure - drug effects
Carbon
Cocos
Dogs
Dopamine - metabolism
Dopamine - pharmacology
Epinephrine - blood
Epinephrine - pharmacology
Extracorporeal Circulation
Glass
Heart Rate - drug effects
Isoproterenol - blood
Isoproterenol - pharmacology
Kinetics
Male
Methoxamine - blood
Methoxamine - pharmacology
Norepinephrine - blood
Norepinephrine - pharmacology
Sympathomimetics - blood
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Zusammenfassung:Sympathomimetic agents with mixed and pure alpha and beta adrenergic activity are adsorbed by coconut shell activated carbon from blood, sufficiently rapidly to markedly reduce the activity of these agents. The results of this study suggest that the site of injection of sympathomimetic agents being considered for correcting hypotension during activated carbon hemoperfusion be selected to permit systemic mixing before circulation into the adsorption device.
ISSN:0066-0078