Tolerance to Marijuana–Induced Tachycardia in Man

Tolerance to Marijuana–Induced Tachycardia in Man

Twenty–seven days exposure of 10 male volunteers to marijuana cigarettes containing a total dose of 16 mg of Δ9–tetrahydrocannabinol resulted in a significant reduction in the effect of the drug on heart rate. The results are consistent with and best explained by the hypothesis of tolerance developm...

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Veröffentlicht in:Acta pharmacologica et toxicologica 1976-07, Vol.39 (1), p.65-76
Hauptverfasser: Gibbins, Robert J., McDougall, Janet, Miles, C. G., Marshman, Joan A.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Cannabis - administration & dosage
Cannabis - pharmacology
cannabis sativa
cardiac effects
chronic administration
Clinical Trials as Topic
Delta–9–tetrahydrocannabinol (A–9–THC)
Dronabinol - pharmacology
Heart Rate - drug effects
Humans
Male
marijuana
Phytotherapy
Placebos
Pulse - drug effects
tachycardia
Time Factors
tolerance
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Beschreibung
Zusammenfassung:Twenty–seven days exposure of 10 male volunteers to marijuana cigarettes containing a total dose of 16 mg of Δ9–tetrahydrocannabinol resulted in a significant reduction in the effect of the drug on heart rate. The results are consistent with and best explained by the hypothesis of tolerance development.
ISSN:0001-6683
1600-0773
DOI:10.1111/j.1600-0773.1976.tb03157.x