Corticotropin releasing factor (CRF) activity in rat plasma

Corticotropin releasing factor (CRF) activity in rat plasma

The ACTH-releasing activity of hypothalamic extract and rat plasma was examined with the dispersed rat pituitary cell technique of Swallow and Sayer (8). Although both plasma and serum caused ACTH release which was dose-related, stress did not enhance the ACTH releasing activity. Furthermore, separa...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1976-09, Vol.152 (4), p.691-694
Hauptverfasser: Kendall, J W, Gray, D K, Gaudette, N D
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Corticotropin-Releasing Hormone - blood
Dose-Response Relationship, Drug
Hypothalamus - analysis
Rats - blood
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Zusammenfassung:The ACTH-releasing activity of hypothalamic extract and rat plasma was examined with the dispersed rat pituitary cell technique of Swallow and Sayer (8). Although both plasma and serum caused ACTH release which was dose-related, stress did not enhance the ACTH releasing activity. Furthermore, separation studies of plasma using ultrafiltration and gel separation suggest that the CRF activity in plasma is associated with molecules of a molecular weight greater than 15,000.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-152-39468