Interpretation of Distribution Coefficients of p‐Alkylpyridines by a Modified Regular Solution Theory

The hypothetical hexadecane–octane distribution coefficients for the alkylpyridines were deduced from the corresponding oil–water distribution data. The values were analyzed by a modified regular solution theory. A good correlation was noted by including the Flory–Huggins entropy factor in the calcu...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1976-05, Vol.65 (5), p.743-745
Hauptverfasser:	Yeh, Kuang C., Higuchi, William I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylpyridines-distribution coefficients interpreted Alkylpyridines—distribution coefficients interpreted, modified regular solution theory Chemical Phenomena Chemistry Distribution coefficients-alkylpyridines Distribution coefficients—alkylpyridines, interpreted by modified regular solution theory Hydrocarbons interpreted by modified regular solution theory modified regular solution theory Oils Picolines Pyridines Solubility Water
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Zusammenfassung:	The hypothetical hexadecane–octane distribution coefficients for the alkylpyridines were deduced from the corresponding oil–water distribution data. The values were analyzed by a modified regular solution theory. A good correlation was noted by including the Flory–Huggins entropy factor in the calculation and by considering the deviation from the geometric mean assumption.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600650531