A family with a high risk of segregation for an autosomal unbalanced reciprocal translocation

A family with a high risk of segregation for an autosomal unbalanced reciprocal translocation

A family with autosomal reciprocal translocation t(4;13) (q25;a31) with a sibship comprising 2 children with unbalanced karyotypes, der(13) partial trisomy 4q, 1 child with the balanced translocation, and 2 abortions were studied. The segregation risk of unbalanced derivation in reciprocal transloca...

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Veröffentlicht in:Human genetics 1976-01, Vol.32 (3), p.343-348
Hauptverfasser: Nielsen, J, Rasmussen, K, Lassen, L B, Christansen, F
Format: Artikel
Sprache:eng
Schlagworte:
Child
Chromosome Aberrations
Chromosomes, Human, 13-15
Chromosomes, Human, 4-5
Female
Humans
Infant
Meiosis
Pedigree
Phenotype
Translocation, Genetic
Trisomy
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Zusammenfassung:A family with autosomal reciprocal translocation t(4;13) (q25;a31) with a sibship comprising 2 children with unbalanced karyotypes, der(13) partial trisomy 4q, 1 child with the balanced translocation, and 2 abortions were studied. The segregation risk of unbalanced derivation in reciprocal translocations is discussed. The clinical picture of the 2 children with partial trisomy 4q is compared with similar cases.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00295827