Cystinuria: In vitro Demonstration of an Intestinal Transport Defect
A defect in the transport of L-cystine and L-lysine has been found in the intestinal mucosa of patients with cystinuria. Transport studies in normal intestinal mucosa, in contrast to similar studies in the kidney, show that cystine and lysine are mutually inhibitory.
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1964-01, Vol.143 (3605), p.482-484 |
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| container_end_page | 484 |
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| container_issue | 3605 |
| container_start_page | 482 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 143 |
| creator | Thier, Samuel Fox, Maurice Segal, Stanton Rosenberg, Leon E. |
| description | A defect in the transport of L-cystine and L-lysine has been found in the intestinal mucosa of patients with cystinuria. Transport studies in normal intestinal mucosa, in contrast to similar studies in the kidney, show that cystine and lysine are mutually inhibitory. |
| doi_str_mv | 10.1126/science.143.3605.482 |
| format | Article |
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Transport studies in normal intestinal mucosa, in contrast to similar studies in the kidney, show that cystine and lysine are mutually inhibitory.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.143.3605.482</identifier><identifier>PMID: 14080318</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Amino acids ; Arginine ; Biological Transport ; Capsules ; Cystine ; Cystinuria ; Electrodes ; Excretion ; Flasks ; Glycine ; Humans ; In Vitro Techniques ; Intestinal Mucosa ; Jejunum ; Kidney ; Kidneys ; Lysine ; Mucosa ; Muscle spindles ; Old Medline ; Proteins - metabolism</subject><ispartof>Science (American Association for the Advancement of Science), 1964-01, Vol.143 (3605), p.482-484</ispartof><rights>Copyright 1964 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-ec751e4557bea3a117892cf14420a7ddd2890b2e69a9811b70972806fbc1c9ef3</citedby><cites>FETCH-LOGICAL-c420t-ec751e4557bea3a117892cf14420a7ddd2890b2e69a9811b70972806fbc1c9ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1712064$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1712064$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14080318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thier, Samuel</creatorcontrib><creatorcontrib>Fox, Maurice</creatorcontrib><creatorcontrib>Segal, Stanton</creatorcontrib><creatorcontrib>Rosenberg, Leon E.</creatorcontrib><title>Cystinuria: In vitro Demonstration of an Intestinal Transport Defect</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>A defect in the transport of L-cystine and L-lysine has been found in the intestinal mucosa of patients with cystinuria. Transport studies in normal intestinal mucosa, in contrast to similar studies in the kidney, show that cystine and lysine are mutually inhibitory.</description><subject>Amino acids</subject><subject>Arginine</subject><subject>Biological Transport</subject><subject>Capsules</subject><subject>Cystine</subject><subject>Cystinuria</subject><subject>Electrodes</subject><subject>Excretion</subject><subject>Flasks</subject><subject>Glycine</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Intestinal Mucosa</subject><subject>Jejunum</subject><subject>Kidney</subject><subject>Kidneys</subject><subject>Lysine</subject><subject>Mucosa</subject><subject>Muscle spindles</subject><subject>Old Medline</subject><subject>Proteins - metabolism</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1964</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtqwzAQRUVpadK0fxCKV93ZHT1sSd2VpI9AoJt0LWRZBgfbSiWl0L-vQgxZzeKeexkOQksMBcakeg6ms6OxBWa0oBWUBRPkCs0xyDKXBOg1mgPQKhfAyxm6C2EPkDJJb9EMMxBAsZij9eovxG48-k6_ZJsx--2id9naDm4M0evYuTFzbabHFEZ7QnWf7bwew8H5mMDWmniPblrdB_sw3QX6fn_brT7z7dfHZvW6zQ0jEHNreIktK0teW001xlxIYlrMUqp50zRESKiJraSWAuOag-REQNXWBhtpW7pAT-fdg3c_x_SNGrpgbN_r0bpjUIIyzjktE8jOoPEuBG9bdfDdoP2fwqBO9tRkTyV76mRPJXup9jjtH-vBNpfSpCsByzOwD9H5S84xgYrRfx-ldg4</recordid><startdate>19640131</startdate><enddate>19640131</enddate><creator>Thier, Samuel</creator><creator>Fox, Maurice</creator><creator>Segal, Stanton</creator><creator>Rosenberg, Leon E.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19640131</creationdate><title>Cystinuria: In vitro Demonstration of an Intestinal Transport Defect</title><author>Thier, Samuel ; Fox, Maurice ; Segal, Stanton ; Rosenberg, Leon E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-ec751e4557bea3a117892cf14420a7ddd2890b2e69a9811b70972806fbc1c9ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1964</creationdate><topic>Amino acids</topic><topic>Arginine</topic><topic>Biological Transport</topic><topic>Capsules</topic><topic>Cystine</topic><topic>Cystinuria</topic><topic>Electrodes</topic><topic>Excretion</topic><topic>Flasks</topic><topic>Glycine</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Intestinal Mucosa</topic><topic>Jejunum</topic><topic>Kidney</topic><topic>Kidneys</topic><topic>Lysine</topic><topic>Mucosa</topic><topic>Muscle spindles</topic><topic>Old Medline</topic><topic>Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thier, Samuel</creatorcontrib><creatorcontrib>Fox, Maurice</creatorcontrib><creatorcontrib>Segal, Stanton</creatorcontrib><creatorcontrib>Rosenberg, Leon E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thier, Samuel</au><au>Fox, Maurice</au><au>Segal, Stanton</au><au>Rosenberg, Leon E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cystinuria: In vitro Demonstration of an Intestinal Transport Defect</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1964-01-31</date><risdate>1964</risdate><volume>143</volume><issue>3605</issue><spage>482</spage><epage>484</epage><pages>482-484</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>A defect in the transport of L-cystine and L-lysine has been found in the intestinal mucosa of patients with cystinuria. Transport studies in normal intestinal mucosa, in contrast to similar studies in the kidney, show that cystine and lysine are mutually inhibitory.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>14080318</pmid><doi>10.1126/science.143.3605.482</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1964-01, Vol.143 (3605), p.482-484 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83477735 |
| source | American Association for the Advancement of Science; MEDLINE; JSTOR |
| subjects | Amino acids Arginine Biological Transport Capsules Cystine Cystinuria Electrodes Excretion Flasks Glycine Humans In Vitro Techniques Intestinal Mucosa Jejunum Kidney Kidneys Lysine Mucosa Muscle spindles Old Medline Proteins - metabolism |
| title | Cystinuria: In vitro Demonstration of an Intestinal Transport Defect |
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