Cystinuria: In vitro Demonstration of an Intestinal Transport Defect

Cystinuria: In vitro Demonstration of an Intestinal Transport Defect

A defect in the transport of L-cystine and L-lysine has been found in the intestinal mucosa of patients with cystinuria. Transport studies in normal intestinal mucosa, in contrast to similar studies in the kidney, show that cystine and lysine are mutually inhibitory.

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1964-01, Vol.143 (3605), p.482-484
Hauptverfasser: Thier, Samuel, Fox, Maurice, Segal, Stanton, Rosenberg, Leon E.
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Arginine
Biological Transport
Capsules
Cystine
Cystinuria
Electrodes
Excretion
Flasks
Glycine
Humans
In Vitro Techniques
Intestinal Mucosa
Jejunum
Kidney
Kidneys
Lysine
Mucosa
Muscle spindles
Old Medline
Proteins - metabolism
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Beschreibung
Zusammenfassung:A defect in the transport of L-cystine and L-lysine has been found in the intestinal mucosa of patients with cystinuria. Transport studies in normal intestinal mucosa, in contrast to similar studies in the kidney, show that cystine and lysine are mutually inhibitory.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.143.3605.482