Effect of Bendroflumethiazide on Na+ and Ca++ Transport in Rat and Guinea Pig Jejunum
The effect of therapeutic bendroflumethiazide (BHFT) concentrations on transepithelial Na+ and Ca++ transport in the rat and guinea pig jejunum was studied by the Ussing technique. In the rat a relative depression of Na+ and Ca++ fluxes from the mucosa to serosa as well as a relative increase of the...
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| Veröffentlicht in: | Acta pharmacologica et toxicologica 1976-07, Vol.39 (1), p.1-6 |
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| container_title | Acta pharmacologica et toxicologica |
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| creator | Jorgensen, F S Rask-Madsen, J |
| description | The effect of therapeutic bendroflumethiazide (BHFT) concentrations on transepithelial Na+ and Ca++ transport in the rat and guinea pig jejunum was studied by the Ussing technique. In the rat a relative depression of Na+ and Ca++ fluxes from the mucosa to serosa as well as a relative increase of the opposite Na+ flux was observed. These effects suggest an inhibition of BHFT on Na+ and Ca++ absorption, which may prevent the development of a positive Ca++ balance during long–term thiazide administration. No consistent changes were found in the guinea pig – either in Na+ or in Ca++ transport. |
| doi_str_mv | 10.1111/j.1600-0773.1976.tb03149.x |
| format | Article |
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In the rat a relative depression of Na+ and Ca++ fluxes from the mucosa to serosa as well as a relative increase of the opposite Na+ flux was observed. These effects suggest an inhibition of BHFT on Na+ and Ca++ absorption, which may prevent the development of a positive Ca++ balance during long–term thiazide administration. 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In the rat a relative depression of Na+ and Ca++ fluxes from the mucosa to serosa as well as a relative increase of the opposite Na+ flux was observed. These effects suggest an inhibition of BHFT on Na+ and Ca++ absorption, which may prevent the development of a positive Ca++ balance during long–term thiazide administration. 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In the rat a relative depression of Na+ and Ca++ fluxes from the mucosa to serosa as well as a relative increase of the opposite Na+ flux was observed. These effects suggest an inhibition of BHFT on Na+ and Ca++ absorption, which may prevent the development of a positive Ca++ balance during long–term thiazide administration. No consistent changes were found in the guinea pig – either in Na+ or in Ca++ transport.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>988963</pmid><doi>10.1111/j.1600-0773.1976.tb03149.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Acta pharmacologica et toxicologica, 1976-07, Vol.39 (1), p.1-6 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Absorption active Animals bendroflumethiazide Bendroflumethiazide - pharmacology biological transport Biological Transport, Active - drug effects Ca++–metabolism Calcium - metabolism cell membrane permeability Cell Membrane Permeability - drug effects electrolytes Guinea Pigs intestinal Intestinal Absorption - drug effects Intestinal Mucosa - metabolism Jejunum - metabolism Male membrane potentials Rats Sodium - metabolism |
| title | Effect of Bendroflumethiazide on Na+ and Ca++ Transport in Rat and Guinea Pig Jejunum |
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