Effect of Bendroflumethiazide on Na+ and Ca++ Transport in Rat and Guinea Pig Jejunum

The effect of therapeutic bendroflumethiazide (BHFT) concentrations on transepithelial Na+ and Ca++ transport in the rat and guinea pig jejunum was studied by the Ussing technique. In the rat a relative depression of Na+ and Ca++ fluxes from the mucosa to serosa as well as a relative increase of the...

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Veröffentlicht in:	Acta pharmacologica et toxicologica 1976-07, Vol.39 (1), p.1-6
Hauptverfasser:	Jorgensen, F S, Rask-Madsen, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption active Animals bendroflumethiazide Bendroflumethiazide - pharmacology biological transport Biological Transport, Active - drug effects Ca++–metabolism Calcium - metabolism cell membrane permeability Cell Membrane Permeability - drug effects electrolytes Guinea Pigs intestinal Intestinal Absorption - drug effects Intestinal Mucosa - metabolism Jejunum - metabolism Male membrane potentials Rats Sodium - metabolism
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Beschreibung
Zusammenfassung:	The effect of therapeutic bendroflumethiazide (BHFT) concentrations on transepithelial Na+ and Ca++ transport in the rat and guinea pig jejunum was studied by the Ussing technique. In the rat a relative depression of Na+ and Ca++ fluxes from the mucosa to serosa as well as a relative increase of the opposite Na+ flux was observed. These effects suggest an inhibition of BHFT on Na+ and Ca++ absorption, which may prevent the development of a positive Ca++ balance during long–term thiazide administration. No consistent changes were found in the guinea pig – either in Na+ or in Ca++ transport.
ISSN:	0001-6683 1600-0773
DOI:	10.1111/j.1600-0773.1976.tb03149.x