In vitro preservation of whole organs by hypothermia and hyperbaric oxygenation

In vitro preservation of whole organs by hypothermia and hyperbaric oxygenation

Canine whole organs (kidney, heart, small bowel) have been successfully preserved for 48 hours in an in vitro viable state by the combination of hypothermia (2 ° to 4 °C) and hyperbaric oxygen up to 7.9 atmospheres absolute. We have presented here the genesis of the method, described its purpose, an...

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Veröffentlicht in:Cryobiology 1964-11, Vol.1 (2), p.181-193
Hauptverfasser: Lillehei, Richard C., Manax, William G., Bloch, Jack H., Eyal, Zwi, Hidalgo, Francisco, Longerbeam, Jerrold K.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Animals
Child
Dogs
Female
Heart Transplantation
Humans
Hyperbaric Oxygenation
Hypothermia, Induced
Ileum - transplantation
Kidney Transplantation
Male
Middle Aged
Tissue Preservation
Transplantation, Homologous
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Beschreibung
Zusammenfassung:Canine whole organs (kidney, heart, small bowel) have been successfully preserved for 48 hours in an in vitro viable state by the combination of hypothermia (2 ° to 4 °C) and hyperbaric oxygen up to 7.9 atmospheres absolute. We have presented here the genesis of the method, described its purpose, and detailed the results of individual experiments, as well as citing pertinent historic data. Clinical applications have also been cited in human renal homotransplantation studies.
ISSN:0011-2240
1090-2392
DOI:10.1016/0011-2240(64)90010-0