Neuraminidases and Influenza Virus Infection in Embryonated Eggs

Neuraminidases and Influenza Virus Infection in Embryonated Eggs

Highly purified neuraminidase from influenza virus prevents embryonated eggs from infection by Lee-B influenza virus. The degree of prevention afforded is equal to that of neuraminidases from Vibrio cholerae and from Clostridium perfringens when assayed at the same enzyme activity. The preventive ef...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1964-03, Vol.143 (3610), p.1051-1052
Hauptverfasser: Johnson, Clarence A., Pekas, Darold J., Winzler, Richard J.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chick Embryo
Eggs
Enzymes
Humans
Infections
Influenza B virus
Influenza, Human
N-Acetylneuraminic Acid
Neuraminidase
Neurons
Old Medline
Orthomyxoviridae
Protective effects
Receptors
Tissue grafting
Vibrio
Vibrio cholerae
Viruses
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Beschreibung
Zusammenfassung:Highly purified neuraminidase from influenza virus prevents embryonated eggs from infection by Lee-B influenza virus. The degree of prevention afforded is equal to that of neuraminidases from Vibrio cholerae and from Clostridium perfringens when assayed at the same enzyme activity. The preventive effect is much lower against PR-8 virus. The results support the concept that the intact "receptor" containing sialic acid is required for the binding and infection of cells by influenza viruses.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.143.3610.1051