D- and l-Amphetamine differentially mediates self-stimulation in rat dorsal midbrain area

Intracranial self-stimulation (ICSS) response rates elicited from the dorsal noradrenergic bundle are enchanced by d-amphetamine but not by l-amphetamine, suggesting noradrenergic mediation. Both isomers equally enhance ICSS response rates elicited from the mid-ventral periaqueductal area (the oculo...

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Veröffentlicht in:	Physiology & behavior 1976, Vol.16 (1), p.1-7
Hauptverfasser:	Ellman, Steven J., Ackermann, Robert F., Bodnar, Richard J., Jackler, Frances, Steiner, Solomon S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamine - pharmacology Animals Conditioning, Operant - drug effects d- and l-Amphetamine Dextroamphetamine - pharmacology Dopamine Dopamine - metabolism Dorsal noradrenergic bundle Dose-Response Relationship, Drug Intracranial self-stimulation Isomerism Male Mesencephalon - drug effects Mesencephalon - metabolism Norepinephrine Norepinephrine - metabolism Periaqueductal midbrain Rats Self Stimulation - drug effects Substantia Nigra - drug effects Substantia Nigra - metabolism Tegmentum Mesencephali - drug effects Tegmentum Mesencephali - metabolism
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Zusammenfassung:	Intracranial self-stimulation (ICSS) response rates elicited from the dorsal noradrenergic bundle are enchanced by d-amphetamine but not by l-amphetamine, suggesting noradrenergic mediation. Both isomers equally enhance ICSS response rates elicited from the mid-ventral periaqueductal area (the oculomotor nuclei, the interstitial nuclei, the dorsal raphe nuclei, and the medial longitudinal fasciculus), suggesting dopaminergic mediation.
ISSN:	0031-9384 1873-507X
DOI:	10.1016/0031-9384(76)90184-0