Histologic study of synovial tissue following oral and intra‐articular administration of phenylbutazone

Fifty‐one synovial biopsies were obtained from the knee joints of 11 patients with rheumatoid arthritis and eight patients with osteoarthritis. Biopsies were taken before and repeated 3–9 days after treatment with phenylbutazone administered orally or intra‐articularly. Histologic comparisons were made with reference to fibrin and fibrinopurulent material, appearance and thickness of synovial lining cells, edema, stromal hyalinization, inflammatory cell type and distribution, vascular alterations and other changes as noted on hematoxylin and eosin and special stained sections. Un total de 51 biopsias esseva effectuate in le articulationes geniculari de 11 patientes con arthritis rheumatoide e 8 patientes con osteoarthritis. Le specimens bioptic esseva obtenite (1) ante e de novo (2) inter 3 e 9 dies post le administration de phenylbutazona per via oral o intra‐articular. Comparationes histologic esseva effectuate con respecto a fibrina e a materiales fibrinopurulente, al apparentia e spissitate del revestimento synovio‐cellulari, al presentia de edema, de hyalinisation stromal, e de alterationes inflammatori (con attention prestate al typo cellular e al distribution), a alterationes vasculari, e a altere processos pathologic notate in sectiones tincturate con hematoxylina e eosina o con colorantes special.