Ingestion of Streptococcus mutans Induces Secretory Immunoglobulin A and Caries Immunity

Ingestion of Streptococcus mutans Induces Secretory Immunoglobulin A and Caries Immunity

Ingestion of killed cells of a highly cariogenic strain of Streptococcus mutans induced specific antibodies in both saliva and milk but not in serum of gnotobiotic rats. These antibodies were associated with the immunoglobulin A class. When infected with Streptococcus mutans, orally immunized animal...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Science (American Association for the Advancement of Science) 1976-06, Vol.192 (4245), p.1238-1240
Hauptverfasser: Michalek, Suzanne M., McGhee, Jerry R., Mestecky, Jiri, Arnold, Roland R., Bozzo, Lourenco
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Agglutinins
Animals
Antibodies
Antigens
Dental Caries - immunology
Dental Caries - prevention & control
Germ-Free Life
Immunization - methods
Immunoglobulin A - biosynthesis
Immunoglobulins
Lymphocytes
Male animals
Mating behavior
Milk - immunology
Rats
Saliva
Saliva - immunology
Streptococcus - immunology
Streptococcus mutans
Streptococcus mutans - immunology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Ingestion of killed cells of a highly cariogenic strain of Streptococcus mutans induced specific antibodies in both saliva and milk but not in serum of gnotobiotic rats. These antibodies were associated with the immunoglobulin A class. When infected with Streptococcus mutans, orally immunized animals developed significantly fewer carious lesions than nonimmunized infected controls.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1273589