Investigation of Danazol as a contraceptive agent

Danazol, the 2,3-isoxasol derivative of 17 α-ethinyl testosterone, was administered to 17 healthy volunteers during the first 7 days of the menstrual cycle, to see if an inadequate luteal phase would result. The follicular span was lengthened, and FSH levels either did not increase or were lowered during Danazol dosage in most women. Although delayed, the LH surge was normal, and a normal progesterone output was documented during the luteal phase. Thus, an inadequate luteal phase was not induced by inhibition of FSH-stimulated follicular development.