Synthesis of platelet-aggregating factor by human platelet microsomes

Synthesis of platelet-aggregating factor by human platelet microsomes

The microsomal fraction of human platelets catalyzed the conversion of arachidonic acid to an unstable factor that induced platelet aggregation. Formation of a polar product, similar in properties to thromboxane B γ, was also demonstrated. Indomethacin and fenoprofen (2-phenoxyphenyl-propionic acid)...

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Veröffentlicht in:Biochemical and biophysical research communications 1976-03, Vol.69 (1), p.218-224
Hauptverfasser: Ho, P.P.K., Walters, C.P., Hermann, R.G.
Format: Artikel
Sprache:eng
Schlagworte:
Aspirin - pharmacology
Blood Coagulation Factors - metabolism
Blood Platelets - metabolism
Drug Stability
Fenoprofen - pharmacology
Humans
Indomethacin - pharmacology
Microsomes - drug effects
Microsomes - metabolism
Platelet Aggregation - drug effects
Time Factors
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Zusammenfassung:The microsomal fraction of human platelets catalyzed the conversion of arachidonic acid to an unstable factor that induced platelet aggregation. Formation of a polar product, similar in properties to thromboxane B γ, was also demonstrated. Indomethacin and fenoprofen (2-phenoxyphenyl-propionic acid) inhibited this enzymatic activity, while preincubation with enzyme protein was necessary for aspirin to exert an inhibitory effect.
ISSN:0006-291X
1090-2104
DOI:10.1016/S0006-291X(76)80295-1