ANTIBIOTIC DE-3936, A POLYETHER ANTIBIOTIC IDENTICAL WITH LONOMYCIN: TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

ANTIBIOTIC DE-3936, A POLYETHER ANTIBIOTIC IDENTICAL WITH LONOMYCIN: TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

Antibiotic DE-3936 was isolated from the fermentation broth of a streptomycete No. 9735-1, which is identified as a strain of Streptomyces hygroscopicus. The antibiotic is a hydrophobic compound having the molecular formula of C44H75O14Na and is active against Gram-positive bacteria, mycobacteria, m...

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Veröffentlicht in:Journal of antibiotics 1976, Vol.29(4), pp.354-365
Hauptverfasser: OHSHIMA, MASAYUKI, ISHIZAKI, NOBORU, ABE, KIMIHIKO, UKAWA, MASUFUMI, MARUMOTO, YASUMASA, NAKATSUKA, KAZUNOBU, HORIUCHI, TADASHI, TONOOKA, YASUAKI, YOSHINO, SHUICHIRO, KANDA, NOBUO
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anti-Bacterial Agents - analysis
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Chemical Phenomena
Chemistry, Physical
Crystallization
Ethers - analysis
Ethers - biosynthesis
Ethers - pharmacology
Fermentation
Fungi - drug effects
Mice
Streptomyces - metabolism
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Beschreibung
Zusammenfassung:Antibiotic DE-3936 was isolated from the fermentation broth of a streptomycete No. 9735-1, which is identified as a strain of Streptomyces hygroscopicus. The antibiotic is a hydrophobic compound having the molecular formula of C44H75O14Na and is active against Gram-positive bacteria, mycobacteria, mycoplasma and protozoa. especially coccidia. Its chemical and biological properties indicate that antibiotic DE-3936 belongs to the group of polyether antibiotics and is identical with lonomycin.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.29.354