Persistent Mitosis of Transfused Homologous Leukocytes in Children Receiving Antileukemic Therapy

Temporary homologous bone marrow grafts were observed in three patients with acute leukemia, receiving intensive antileukemic treatment, following transfusion of peripheral blood cells from donors with chronic myelocytic leukemia. Persistent mitosis of the transfused cells, containing the Philadelph...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1963-12, Vol.142 (3597), p.1305-1311
Hauptverfasser:	Levin, Robert H., Whang, Jacqueline, Tjio, J. H., Carbone, Paul P., Frei, Emil, Freireich, Emil J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents Blood Blood cells Blood donation Blood Transfusion Bone marrow Bone Marrow Transplantation Cell Division Child Chromosomes Erythroid cells Granulocytes Humans Leukemia Leukemia, Lymphoid Leukemia, Myelogenous, Chronic, BCR-ABL Positive Leukocytes Liver Lymphocytes Mitosis Old Medline
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Beschreibung
Zusammenfassung:	Temporary homologous bone marrow grafts were observed in three patients with acute leukemia, receiving intensive antileukemic treatment, following transfusion of peripheral blood cells from donors with chronic myelocytic leukemia. Persistent mitosis of the transfused cells, containing the Philadelphia chromosome marker, were detected by cytogenetic techniques 19, 39, and 52 days after transfusion.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.142.3597.1305