Incorporation of DNA into a mouse tumor in vivo and in vitro

Incorporation of DNA into a mouse tumor in vivo and in vitro

14C-formate labeled deoxyribonucleic acid (DNA) from BDF 1T ascites tumor proved to have a specific activity of its bases different from the DNA of the same tumor cells grown in vitro. This radiochemical marking has been utilized to study the penetration of DNA molecules into living cells. It would...

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Veröffentlicht in:Experimental cell research 1963-09, Vol.31 (3), p.562-565
1. Verfasser: Rabotti, G.F.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
DNA
DNA, Neoplasm
In Vitro Techniques
Metabolism
Mice
Neoplasms
Neoplasms, Experimental
Old Medline
Tissue Culture Techniques
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Zusammenfassung:14C-formate labeled deoxyribonucleic acid (DNA) from BDF 1T ascites tumor proved to have a specific activity of its bases different from the DNA of the same tumor cells grown in vitro. This radiochemical marking has been utilized to study the penetration of DNA molecules into living cells. It would appear that under certain conditions, this is likely to happen. The radiochemical marking is presented as a tool for the study of mammalian cell transformation.
ISSN:0014-4827
1090-2422
DOI:10.1016/0014-4827(63)90402-6