Effects of perhexiline maleate on coronary flow distribution in the ischemic canine myocardium
Intravenous perhexiline maleate in a canine preparation with fixed coronary flow increases coronary diastolic pressure. It also redistributes coronary flow so as to preserve endocardial flow. Myocardial oxygen consumption was reduced and lactate uptake enhanced by the drug. It had no effect upon the...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1976-07, Vol.54 (1), p.14-20 |
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| container_title | Circulation (New York, N.Y.) |
| container_volume | 54 |
| creator | Klassen, G A Sestier, F L'Abbate, A Mildenberger, R R Zborowska-Sluis, D T |
| description | Intravenous perhexiline maleate in a canine preparation with fixed coronary flow increases coronary diastolic pressure. It also redistributes coronary flow so as to preserve endocardial flow. Myocardial oxygen consumption was reduced and lactate uptake enhanced by the drug. It had no effect upon the threshold for ischemic-induced left ventricular failure. |
| doi_str_mv | 10.1161/01.CIR.54.1.14 |
| format | Article |
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It also redistributes coronary flow so as to preserve endocardial flow. Myocardial oxygen consumption was reduced and lactate uptake enhanced by the drug. 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| fulltext | fulltext |
| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 1976-07, Vol.54 (1), p.14-20 |
| issn | 0009-7322 1524-4539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83326739 |
| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Coronary Circulation - drug effects Coronary Disease - drug therapy Coronary Disease - physiopathology Dogs Lung - blood supply Myocardium - metabolism Oxygen Consumption Perhexiline - pharmacology Perhexiline - therapeutic use Piperidines - pharmacology |
| title | Effects of perhexiline maleate on coronary flow distribution in the ischemic canine myocardium |
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