Effects of perhexiline maleate on coronary flow distribution in the ischemic canine myocardium

Intravenous perhexiline maleate in a canine preparation with fixed coronary flow increases coronary diastolic pressure. It also redistributes coronary flow so as to preserve endocardial flow. Myocardial oxygen consumption was reduced and lactate uptake enhanced by the drug. It had no effect upon the...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1976-07, Vol.54 (1), p.14-20
Hauptverfasser:	Klassen, G A, Sestier, F, L'Abbate, A, Mildenberger, R R, Zborowska-Sluis, D T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Coronary Circulation - drug effects Coronary Disease - drug therapy Coronary Disease - physiopathology Dogs Lung - blood supply Myocardium - metabolism Oxygen Consumption Perhexiline - pharmacology Perhexiline - therapeutic use Piperidines - pharmacology
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Zusammenfassung:	Intravenous perhexiline maleate in a canine preparation with fixed coronary flow increases coronary diastolic pressure. It also redistributes coronary flow so as to preserve endocardial flow. Myocardial oxygen consumption was reduced and lactate uptake enhanced by the drug. It had no effect upon the threshold for ischemic-induced left ventricular failure.
ISSN:	0009-7322 1524-4539
DOI:	10.1161/01.CIR.54.1.14