Small bowel mucosal dysfunction in patients with cystic fibrosis

Jejunal biopsies were obtained from 37 children with cystic fibrosis, 16 with gluten-induced enteropathy, and 18 control subjects for the following studies: (1) disaccharidase activity, (2) L-ALA-L-Phe hydrolase activity, and (3) intestinal uptake of three 14C-labeled amino acids. Values were signif...

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Veröffentlicht in:	The Journal of pediatrics 1976-02, Vol.88 (2), p.213-216
Hauptverfasser:	Morin, Claude L., Roy, Claude C., Lasalle, Roger, Bonin, André
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Celiac Disease - enzymology Celiac Disease - metabolism Child Child, Preschool Cycloleucine - metabolism Cystic Fibrosis - complications Cystic Fibrosis - enzymology Cystic Fibrosis - metabolism Dipeptidases - metabolism Disaccharidases - metabolism Humans Intestinal Mucosa - enzymology Intestinal Mucosa - metabolism Intestine, Small - enzymology Intestine, Small - metabolism Lysine - metabolism Malabsorption Syndromes - enzymology Malabsorption Syndromes - etiology Malabsorption Syndromes - metabolism Phenylalanine - metabolism
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Zusammenfassung:	Jejunal biopsies were obtained from 37 children with cystic fibrosis, 16 with gluten-induced enteropathy, and 18 control subjects for the following studies: (1) disaccharidase activity, (2) L-ALA-L-Phe hydrolase activity, and (3) intestinal uptake of three 14C-labeled amino acids. Values were significantly reduced in the three determinations in patients with gluten-induced enteropathy as compared to control subjects. Lactase and L-ALA-L-Phe hydrolase activities were significantly reduced (p
ISSN:	0022-3476 1097-6833
DOI:	10.1016/S0022-3476(76)80984-5