Increased Sarcoma Virus RNA in Cells Transformed by Leukemia Viruses: Model for Leukemogenesis
A morphologically flat revertant of mink cells nonproductively infected with Moloney sarcoma virus exhibited contact inhibition and lacked detectable sarcoma virus RNA. Superinfection by usually nontransforming type C mammalian leukemia-causing viruses induced transformation and increased sarcoma vi...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1976-06, Vol.192 (4244), p.1143-1145 |
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| container_issue | 4244 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Peebles, Paul T. Scolnick, Edward M. Howk, Richard S. |
| description | A morphologically flat revertant of mink cells nonproductively infected with Moloney sarcoma virus exhibited contact inhibition and lacked detectable sarcoma virus RNA. Superinfection by usually nontransforming type C mammalian leukemia-causing viruses induced transformation and increased sarcoma virus RNA. The results suggest a model for leukemogenesis in animals by increasing, during replication of usually nontransforming leukemia viruses, the levels of RNA from potentially oncogenic cell or integrated virus transforming genes. |
| doi_str_mv | 10.1126/science.179144 |
| format | Article |
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Superinfection by usually nontransforming type C mammalian leukemia-causing viruses induced transformation and increased sarcoma virus RNA. The results suggest a model for leukemogenesis in animals by increasing, during replication of usually nontransforming leukemia viruses, the levels of RNA from potentially oncogenic cell or integrated virus transforming genes.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.179144</identifier><identifier>PMID: 179144</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Cell culture techniques ; Cell lines ; Cell Transformation, Neoplastic ; Defective Viruses ; Helper Viruses ; Leukemia ; Leukemia - etiology ; Mink ; Models, Biological ; Moloney murine leukemia virus - analysis ; Moloney murine leukemia virus - metabolism ; Nerves ; Retroviridae ; RNA ; RNA, Viral - analysis ; RNA, Viral - metabolism ; Sarcoma ; Superinfection ; Virus Replication ; Viruses</subject><ispartof>Science (American Association for the Advancement of Science), 1976-06, Vol.192 (4244), p.1143-1145</ispartof><rights>Copyright 1976 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c341t-32ef315c05e5f7ad22adf17a244ce4c3b653bcc99f78fd674ed2539f785469273</citedby><cites>FETCH-LOGICAL-c341t-32ef315c05e5f7ad22adf17a244ce4c3b653bcc99f78fd674ed2539f785469273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1742918$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1742918$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/179144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peebles, Paul T.</creatorcontrib><creatorcontrib>Scolnick, Edward M.</creatorcontrib><creatorcontrib>Howk, Richard S.</creatorcontrib><title>Increased Sarcoma Virus RNA in Cells Transformed by Leukemia Viruses: Model for Leukemogenesis</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>A morphologically flat revertant of mink cells nonproductively infected with Moloney sarcoma virus exhibited contact inhibition and lacked detectable sarcoma virus RNA. Superinfection by usually nontransforming type C mammalian leukemia-causing viruses induced transformation and increased sarcoma virus RNA. The results suggest a model for leukemogenesis in animals by increasing, during replication of usually nontransforming leukemia viruses, the levels of RNA from potentially oncogenic cell or integrated virus transforming genes.</description><subject>Cell culture techniques</subject><subject>Cell lines</subject><subject>Cell Transformation, Neoplastic</subject><subject>Defective Viruses</subject><subject>Helper Viruses</subject><subject>Leukemia</subject><subject>Leukemia - etiology</subject><subject>Mink</subject><subject>Models, Biological</subject><subject>Moloney murine leukemia virus - analysis</subject><subject>Moloney murine leukemia virus - metabolism</subject><subject>Nerves</subject><subject>Retroviridae</subject><subject>RNA</subject><subject>RNA, Viral - analysis</subject><subject>RNA, Viral - metabolism</subject><subject>Sarcoma</subject><subject>Superinfection</subject><subject>Virus Replication</subject><subject>Viruses</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkDlPw0AQRleIKwRaKoqt6Bz2tL10KOKIFECCQIm1Xs8iBx9hJy7y73EUSyCq0ei9Gc18hJxzNuFcxFfoSmgcTHhiuFJ7ZMSZ0ZERTO6TEWMyjlKW6GNygrhkrGdGHpHDnT0iH7PGBbAIBX21wbW1pe9l6JC-PN3QsqFTqCqki2Ab9G2oey3f0Dl0X1CXgwp4TR_bAiraGwNrP6EBLPGUHHhbIZwNdUze7m4X04do_nw_m97MIycVX0dSgJdcO6ZB-8QWQtjC88QKpRwoJ_NYy9w5Y3yS-iJOFBRCy22nVWxEIsfkcrd3FdrvDnCd1SW6_nbbQNthlkphEsl0L052ogstYgCfrUJZ27DJOMu2eWZDntkuoX7gYtjc5f37v_o_vMR1G_5QJQxP5Q9wnXuv</recordid><startdate>19760611</startdate><enddate>19760611</enddate><creator>Peebles, Paul T.</creator><creator>Scolnick, Edward M.</creator><creator>Howk, Richard S.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19760611</creationdate><title>Increased Sarcoma Virus RNA in Cells Transformed by Leukemia Viruses: Model for Leukemogenesis</title><author>Peebles, Paul T. ; Scolnick, Edward M. ; Howk, Richard S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-32ef315c05e5f7ad22adf17a244ce4c3b653bcc99f78fd674ed2539f785469273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Cell culture techniques</topic><topic>Cell lines</topic><topic>Cell Transformation, Neoplastic</topic><topic>Defective Viruses</topic><topic>Helper Viruses</topic><topic>Leukemia</topic><topic>Leukemia - etiology</topic><topic>Mink</topic><topic>Models, Biological</topic><topic>Moloney murine leukemia virus - analysis</topic><topic>Moloney murine leukemia virus - metabolism</topic><topic>Nerves</topic><topic>Retroviridae</topic><topic>RNA</topic><topic>RNA, Viral - analysis</topic><topic>RNA, Viral - metabolism</topic><topic>Sarcoma</topic><topic>Superinfection</topic><topic>Virus Replication</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peebles, Paul T.</creatorcontrib><creatorcontrib>Scolnick, Edward M.</creatorcontrib><creatorcontrib>Howk, Richard S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peebles, Paul T.</au><au>Scolnick, Edward M.</au><au>Howk, Richard S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Sarcoma Virus RNA in Cells Transformed by Leukemia Viruses: Model for Leukemogenesis</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1976-06-11</date><risdate>1976</risdate><volume>192</volume><issue>4244</issue><spage>1143</spage><epage>1145</epage><pages>1143-1145</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>A morphologically flat revertant of mink cells nonproductively infected with Moloney sarcoma virus exhibited contact inhibition and lacked detectable sarcoma virus RNA. Superinfection by usually nontransforming type C mammalian leukemia-causing viruses induced transformation and increased sarcoma virus RNA. The results suggest a model for leukemogenesis in animals by increasing, during replication of usually nontransforming leukemia viruses, the levels of RNA from potentially oncogenic cell or integrated virus transforming genes.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>179144</pmid><doi>10.1126/science.179144</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1976-06, Vol.192 (4244), p.1143-1145 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83297305 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Cell culture techniques Cell lines Cell Transformation, Neoplastic Defective Viruses Helper Viruses Leukemia Leukemia - etiology Mink Models, Biological Moloney murine leukemia virus - analysis Moloney murine leukemia virus - metabolism Nerves Retroviridae RNA RNA, Viral - analysis RNA, Viral - metabolism Sarcoma Superinfection Virus Replication Viruses |
| title | Increased Sarcoma Virus RNA in Cells Transformed by Leukemia Viruses: Model for Leukemogenesis |
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