Increased Sarcoma Virus RNA in Cells Transformed by Leukemia Viruses: Model for Leukemogenesis

Increased Sarcoma Virus RNA in Cells Transformed by Leukemia Viruses: Model for Leukemogenesis

A morphologically flat revertant of mink cells nonproductively infected with Moloney sarcoma virus exhibited contact inhibition and lacked detectable sarcoma virus RNA. Superinfection by usually nontransforming type C mammalian leukemia-causing viruses induced transformation and increased sarcoma vi...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1976-06, Vol.192 (4244), p.1143-1145
Hauptverfasser: Peebles, Paul T., Scolnick, Edward M., Howk, Richard S.
Format: Artikel
Sprache:eng
Schlagworte:
Cell culture techniques
Cell lines
Cell Transformation, Neoplastic
Defective Viruses
Helper Viruses
Leukemia
Leukemia - etiology
Mink
Models, Biological
Moloney murine leukemia virus - analysis
Moloney murine leukemia virus - metabolism
Nerves
Retroviridae
RNA
RNA, Viral - analysis
RNA, Viral - metabolism
Sarcoma
Superinfection
Virus Replication
Viruses
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Zusammenfassung:A morphologically flat revertant of mink cells nonproductively infected with Moloney sarcoma virus exhibited contact inhibition and lacked detectable sarcoma virus RNA. Superinfection by usually nontransforming type C mammalian leukemia-causing viruses induced transformation and increased sarcoma virus RNA. The results suggest a model for leukemogenesis in animals by increasing, during replication of usually nontransforming leukemia viruses, the levels of RNA from potentially oncogenic cell or integrated virus transforming genes.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.179144