Metabolism of estrone and progesterone in vitro in human saliva

[2,4,6,7 -3H]-estrone and [1,2,6,7 -3]-progesterone were found to be metabolized by saliva of patients with chronic gingival inflammation. No metabolites were detected in saliva of subjects with clinically normal gingiva. By paper and thin-layer chromatography, isotope dilution, and the preparation of acetates and methoximes, the following metabolites were identified: estradiol-17β as the only metabolite of estrone; 5α- and 5β-pregnanediones as metabolites of progesterone.