Different surface glycoprotein patterns on human T‐, B‐ and leukemic‐lymphocytes

We have labeled the exposed surface glycoprotein of human blood T‐ and B‐lymphocytes and cells from patients with chronic lymphocytic leukemia by the galactose oxidase‐tritiated sodium borohydride method. The labeled glycoproteins were separated by polyacrylamide slab gel electrophoresis and visualized by autoradiography. The T‐ and B‐lymphocytes show different and characteristic surface glycoprotein patterns. The surface glcoprotein patterns of the leukemic cells differ from those of normal, non‐malignant lymphocytes. A relationship between the altered surface glycoprotein pattern of leukemic cells and the expression of leumemiaassociated antigens is discussed.