Genetic Characteristics of the HeLa Cell

Genetic Characteristics of the HeLa Cell

The genotype of the patient Henrietta Lacks from whose cervical carcinoma the HeLa cell was derived was deduced from the phenotypes of her husband and children, and from studies of the HeLa cell. Hemizygous expression of glucose-6-phosphate dehydrogenase in HeLa, together with the deduced heterozygo...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1976-01, Vol.191 (4225), p.392-394
Hauptverfasser: Hsu, Susan H., Schacter, Bernice Z., Delaney, Nancy L., Miller, Thomas B., McKusick, Victor A., Kennett, R. H., Bodmer, J. G., Young, D., Bodmer, W. F.
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Cell lines
Female
Genetic markers
Genotype
Glucosephosphate Dehydrogenase - metabolism
HeLa cells
HeLa Cells - enzymology
HeLa Cells - immunology
HLA Antigens
Humans
Isoantigens
Male
Pedigree
Phenotype
Phenotypes
Photoreceptors
Retina
Sex Chromosomes
Somatic cells
Tumor cell line
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Beschreibung
Zusammenfassung:The genotype of the patient Henrietta Lacks from whose cervical carcinoma the HeLa cell was derived was deduced from the phenotypes of her husband and children, and from studies of the HeLa cell. Hemizygous expression of glucose-6-phosphate dehydrogenase in HeLa, together with the deduced heterozygosity of Mrs. Lacks, is consistent with clonal origin of her neoplasm.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1246620