Hæmophilia and the Protease Inhibitor in Peanuts
Boudreaux and Frampton's report 1 on a hæmostatic factor in peanuts ( Arachis hypogaea ), orally active in hæmophilic patients, aroused great interest. Since these and other investigators have been unable to demonstrate restoration of blood coagulation in the treated patients, other mechanisms...
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| Veröffentlicht in: | Nature (London) 1962-06, Vol.194 (4832), p.980-981 |
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| creator | ASTRUP, TAGE BRAKMAN, PIETER SJØLIN, K.-E |
| description | Boudreaux and Frampton's report
1
on a hæmostatic factor in peanuts (
Arachis hypogaea
), orally active in hæmophilic patients, aroused great interest. Since these and other investigators have been unable to demonstrate restoration of blood coagulation in the treated patients, other mechanisms of action were suggested. Boudreaux and Frampton
1
considered vasoconstriction as a possible mechanism and they later found vasoconstrictive agents in ethanol extracts
2
. Verstraete
et al.
3
extracted with ethanol from the skins of peanuts hæmostatically active anthocyanidines and flavones. |
| doi_str_mv | 10.1038/194980b0 |
| format | Article |
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1
on a hæmostatic factor in peanuts (
Arachis hypogaea
), orally active in hæmophilic patients, aroused great interest. Since these and other investigators have been unable to demonstrate restoration of blood coagulation in the treated patients, other mechanisms of action were suggested. Boudreaux and Frampton
1
considered vasoconstriction as a possible mechanism and they later found vasoconstrictive agents in ethanol extracts
2
. Verstraete
et al.
3
extracted with ethanol from the skins of peanuts hæmostatically active anthocyanidines and flavones.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/194980b0</identifier><identifier>PMID: 13863030</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Arachis - chemistry ; Hemophilia A - therapy ; Humanities and Social Sciences ; Humans ; letter ; Medicine ; multidisciplinary ; Old Medline ; Peptide Hydrolases ; Protease Inhibitors ; Science ; Science (multidisciplinary)</subject><ispartof>Nature (London), 1962-06, Vol.194 (4832), p.980-981</ispartof><rights>Springer Nature Limited 1962</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-42f97a802c61bd9d438f748050ec745d141f6e9bf45c26d569caa8fc0a9353cc3</citedby><cites>FETCH-LOGICAL-c338t-42f97a802c61bd9d438f748050ec745d141f6e9bf45c26d569caa8fc0a9353cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/194980b0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/194980b0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13863030$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ASTRUP, TAGE</creatorcontrib><creatorcontrib>BRAKMAN, PIETER</creatorcontrib><creatorcontrib>SJØLIN, K.-E</creatorcontrib><title>Hæmophilia and the Protease Inhibitor in Peanuts</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Boudreaux and Frampton's report
1
on a hæmostatic factor in peanuts (
Arachis hypogaea
), orally active in hæmophilic patients, aroused great interest. Since these and other investigators have been unable to demonstrate restoration of blood coagulation in the treated patients, other mechanisms of action were suggested. Boudreaux and Frampton
1
considered vasoconstriction as a possible mechanism and they later found vasoconstrictive agents in ethanol extracts
2
. Verstraete
et al.
3
extracted with ethanol from the skins of peanuts hæmostatically active anthocyanidines and flavones.</description><subject>Arachis - chemistry</subject><subject>Hemophilia A - therapy</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>letter</subject><subject>Medicine</subject><subject>multidisciplinary</subject><subject>Old Medline</subject><subject>Peptide Hydrolases</subject><subject>Protease Inhibitors</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1962</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90MFKwzAcx_EgiptT8AmkJ9FD9Z8mTZOjDHWDgTvoOaRp6jraZCbpwRfai_hiVraxm6cc8uEL_x9C1xgeMBD-iAUVHEo4QWNMC5ZSxotTNAbIeAqcsBG6CGENADku6DkaYcIZAQJjhGc_285tVk3bqETZKokrkyy9i0YFk8ztqimb6HzS2GRplO1juERntWqDudq_E_Tx8vw-naWLt9f59GmRakJ4TGlWi0JxyDTDZSUqSnhdUA45GF3QvMIU18yIsqa5zliVM6GV4rUGJUhOtCYTdLvrbrz76k2IsmuCNm2rrHF9kJxklBRYDPBuB7V3IXhTy41vOuW_JQb5N488zDPQm32zLztTHeF-jwHc70AYvuyn8XLtem-HO_-JWRV7b46xA_gF3Rx1xw</recordid><startdate>19620609</startdate><enddate>19620609</enddate><creator>ASTRUP, TAGE</creator><creator>BRAKMAN, PIETER</creator><creator>SJØLIN, K.-E</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19620609</creationdate><title>Hæmophilia and the Protease Inhibitor in Peanuts</title><author>ASTRUP, TAGE ; BRAKMAN, PIETER ; SJØLIN, K.-E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-42f97a802c61bd9d438f748050ec745d141f6e9bf45c26d569caa8fc0a9353cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1962</creationdate><topic>Arachis - chemistry</topic><topic>Hemophilia A - therapy</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>letter</topic><topic>Medicine</topic><topic>multidisciplinary</topic><topic>Old Medline</topic><topic>Peptide Hydrolases</topic><topic>Protease Inhibitors</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ASTRUP, TAGE</creatorcontrib><creatorcontrib>BRAKMAN, PIETER</creatorcontrib><creatorcontrib>SJØLIN, K.-E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ASTRUP, TAGE</au><au>BRAKMAN, PIETER</au><au>SJØLIN, K.-E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hæmophilia and the Protease Inhibitor in Peanuts</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1962-06-09</date><risdate>1962</risdate><volume>194</volume><issue>4832</issue><spage>980</spage><epage>981</epage><pages>980-981</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>Boudreaux and Frampton's report
1
on a hæmostatic factor in peanuts (
Arachis hypogaea
), orally active in hæmophilic patients, aroused great interest. Since these and other investigators have been unable to demonstrate restoration of blood coagulation in the treated patients, other mechanisms of action were suggested. Boudreaux and Frampton
1
considered vasoconstriction as a possible mechanism and they later found vasoconstrictive agents in ethanol extracts
2
. Verstraete
et al.
3
extracted with ethanol from the skins of peanuts hæmostatically active anthocyanidines and flavones.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>13863030</pmid><doi>10.1038/194980b0</doi><tpages>2</tpages></addata></record> |
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| issn | 0028-0836 1476-4687 |
| language | eng |
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| source | MEDLINE; Nature; Springer Nature - Complete Springer Journals |
| subjects | Arachis - chemistry Hemophilia A - therapy Humanities and Social Sciences Humans letter Medicine multidisciplinary Old Medline Peptide Hydrolases Protease Inhibitors Science Science (multidisciplinary) |
| title | Hæmophilia and the Protease Inhibitor in Peanuts |
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