Hæmophilia and the Protease Inhibitor in Peanuts

Boudreaux and Frampton's report 1 on a hæmostatic factor in peanuts ( Arachis hypogaea ), orally active in hæmophilic patients, aroused great interest. Since these and other investigators have been unable to demonstrate restoration of blood coagulation in the treated patients, other mechanisms of action were suggested. Boudreaux and Frampton 1 considered vasoconstriction as a possible mechanism and they later found vasoconstrictive agents in ethanol extracts 2 . Verstraete et al. 3 extracted with ethanol from the skins of peanuts hæmostatically active anthocyanidines and flavones.